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The sclera is the protective outer layer of the eye, which is also the white part of the eye. 

Scleritis disease treatment

Sclera of the eye

Scleritis is a disorder in which the sclera becomes severely inflamed and red. It can be very painful. Scleritis is believed to be the result of overreacting body’s immune system. Most people feel severe pain with the condition, but there are exceptions.

Early treatment with medication is necessary to prevent scleritis from progressing. Serious, untreated cases can lead to partial or complete vision loss.

The subtypes of anterior scleritis include:

Anterior scleritis: is the most common form of scleritis
-Nodular anterior scleritis: the second most common form
-Necrotizing anterior scleritis with inflammation: the most serious form of anterior scleritis
-Necrotizing anterior scleritis without inflammation: the rarest form of anterior scleritis

Posterior scleritis: more difficult to diagnose and detect because it has variable symptoms, including many that mimic other disorders.

What are the symptoms of scleritis?
Each type of scleritis has similar symptoms, and they can worsen if the condition isn’t treated. Severe eye pain is the main symptom of scleritis that responds poorly to painkillers. Eye movements are likely to make the pain worse. The pain may spread throughout the entire face, particularly on the side of the affected eye.

Other symptoms may include:
• Redness of the sclera, or white portion of your eye – recurrent episodes of redness with pain
• Excessive tearing, or lacrimation
• Decreased vision
• Blurry vision
• Sensitivity to light, or photophobia.

Some people experience little to no pain from scleritis. This may be because they have:
• Milder case
• Scleromalacia perforans, which is a rare complication of advanced rheumatoid arthritis (RA)
• History of using immunosuppressive medications (they prevent activity in the immune system) before symptoms began

Systemic symptoms – patients suffering from scleritis may experience joint pains, fever, chest pain, cough, dry mouth and other auto-immune diseases related symptoms.

What are the risk factors for scleritis?
Scleritis may occur at any age. Women are more likely to develop it than men. There’s no specific race or area of the world where this condition is more common.

You have an increased chance of developing scleritis if you have:
• Rheumatoid arthritis (RA), which is an autoimmune disorder causing inflammation of the joints
• Inflammatory bowel disease (IBD), which causes digestive symptoms due to inflammation of the bowel
• Sjogren’s syndrome, which is an immune disorder known for causing dry eyes and mouth
• Lupus, an immune disorder that causes skin inflammation
• Wegener’s disease (Wegener’s granulomatosis), which is an uncommon disorder that involves inflammation of the blood vessels
• Eye infections (may or may not be related to autoimmune disease)
• Damage to eye tissues from an accident

How is scleritis diagnosed?
Your doctor will review a detailed medical history and perform an examination and laboratory evaluations to diagnose scleritis.
Your doctor may ask questions about your history of systemic conditions, such as whether you’ve had RA, Wegener’s granulomatosis, or IBD. They may also ask if you’ve had a history of trauma or surgery to the eye.

Other conditions that have symptoms similar to scleritis include / differential diagnosis:
•Episcleritis, which is an inflammation of superficial vessels in the outermost layer of the eye (episclera)
•Blepharitis, which is an inflammation of the outer eye lid
•Viral conjunctivitis, which is an inflammation of the eye caused by a virus
•Bacterial conjunctivitis, which is an inflammation of the eye caused by bacteria.

The following tests can help your doctor make a diagnosis:
• Ultrasonography of eye to look for changes occurring in or around the sclera
• Complete blood count to check for signs of infection and immune system activity
• Erythrocyte sedimentation rate/ ESR to check for signs of chronic infection and immune system activity
• C reactive protein to check for signs of chronic infection and immune system activity
• Mantoux test to check for tuberculosis
• Chest X ray to check for tuberculosis
• Rheumatoid factor to check for rheumatoid arthritis
• Anti Nuclear Antibody/ ANA to check for auto-immune disorders
• May ask for other specific tests depending on systemic history and results of above tests.

How is scleritis treated?
Treatment of scleritis focuses on fighting the inflammation before it can cause permanent damage. Pain from scleritis is also related to inflammation, so reducing inflammation will decrease symptoms.

The treatment follows a stepladder approach. If the first step in medication fails, then the second is used.

Medications used to treat scleritis include the following:
• Nonsteroidal anti-inflammatory drugs (NSAIDs) -  topical steroids are most often used in nodular anterior scleritis. Reducing inflammation also helps to ease scleritis pain.
• Oral Steroids (such as prednisone) may be used if topical steroids don’t reduce inflammation.
• Immunosuppressive drugs with oral glucocorticoids are preferred for the most dangerous form, which is necrotizing scleritis.
• Antibiotics may be used to prevent or treat infections of the sclera.

Surgery may also be necessary for severe cases of scleritis. The process involves the repair of tissues in the sclera to improve muscle function and prevent vision loss.

Sclera treatment may also be contingent on treating the underlying causes. For example, if you have an autoimmune disorder, then effectively treating it will help prevent recurring cases of scleritis.

Scleritis is a serious eye condition that requires prompt treatment, as soon as symptoms are noticed. Even if your symptoms improve, it’s important to follow up with an ophthalmologist on a regular basis to make sure it doesn’t return. Treating underlying autoimmune conditions that might cause scleritis is also important in preventing future problems with the sclera.